Micheaux (or sometimes written as "Michaux"), was born near Metropolis, Illinois and grew up in Great Bend, Kansas, one of eleven children of former slaves. As a young boy he shined shoes and worked as a porter on the railway. As a young man, he very successfully homesteaded a farm in an all-white area of South Dakota where he began writing stories. Given the attitudes and restrictions on black people at the time, Micheaux overcame them by forming his own publishing company to buy his books door-to-house.
The advent of the motion picture industry intrigued him as a vehicle to tell his stories. He formed his own movie production company and in 1919 became the first African-American to make a film. He wrote, directed and produced the silent motion picture The Homesteader, starring the pioneering African American actress Evelyn Preer and based on his novel of the same name. He again used autobiographical elements in The Exile, his first feature film with sound, in which the central character leaves Chicago to buy and operate a ranch in South Dakota. In 1924 he introduced the moviegoing world to Paul Robeson in his film, Body and Soul.
Given the times, his accomplishments in publishing and film are extraordinary, including being the first African-American to produce a film to be shown in "white" movie theaters. In his motion pictures, he moved away from the "Negro" stereotypes being portrayed in film at the time. Additionally, in his film Within Our Gates, Micheaux attacked the racism depicted in D.W. Griffith's film, The Birth of a Nation.